diff --git a/crates/wasmtime/src/engine.rs b/crates/wasmtime/src/engine.rs
index dc6bf416aa..c81ae6e67d 100644
--- a/crates/wasmtime/src/engine.rs
+++ b/crates/wasmtime/src/engine.rs
@@ -390,7 +390,8 @@ impl Engine {
             }
         }
 
-        let enabled;
+        #[allow(unused_assignments)]
+        let mut enabled = None;
 
         #[cfg(target_arch = "aarch64")]
         {
@@ -403,6 +404,24 @@ impl Engine {
             };
         }
 
+        // There is no is_s390x_feature_detected macro yet, so for now
+        // we use getauxval from the libc crate directly.
+        #[cfg(all(target_arch = "s390x", target_os = "linux"))]
+        {
+            let v = unsafe { libc::getauxval(libc::AT_HWCAP) };
+            const HWCAP_S390X_VXRS_EXT2: libc::c_ulong = 32768;
+
+            enabled = match flag {
+                // There is no separate HWCAP bit for mie2, so assume
+                // that any machine with vxrs_ext2 also has mie2.
+                "has_vxrs_ext2" | "has_mie2" => Some((v & HWCAP_S390X_VXRS_EXT2) != 0),
+                // fall through to the very bottom to indicate that support is
+                // not enabled to test whether this feature is enabled on the
+                // host.
+                _ => None,
+            }
+        }
+
         #[cfg(target_arch = "x86_64")]
         {
             enabled = match flag {
@@ -429,11 +448,6 @@ impl Engine {
             };
         }
 
-        #[cfg(not(any(target_arch = "aarch64", target_arch = "x86_64")))]
-        {
-            enabled = None;
-        }
-
         match enabled {
             Some(true) => return Ok(()),
             Some(false) => {