diff --git a/cranelift/codegen/src/isa/x64/inst/emit.rs b/cranelift/codegen/src/isa/x64/inst/emit.rs
index e1253b9597..6622903452 100644
--- a/cranelift/codegen/src/isa/x64/inst/emit.rs
+++ b/cranelift/codegen/src/isa/x64/inst/emit.rs
@@ -3016,6 +3016,19 @@ pub(crate) fn emit(
             );
             sink.put4(0); // offset
         }
+
+        Inst::MachOTlsGetAddr { ref symbol } => {
+            // movq gv@tlv(%rip), %rdi
+            sink.put1(0x48); // REX.w
+            sink.put1(0x8b); // MOV
+            sink.put1(0x3d); // ModRM byte
+            emit_reloc(sink, state, Reloc::MachOX86_64Tlv, symbol, -4);
+            sink.put4(0); // offset
+
+            // callq *(%rdi)
+            sink.put1(0xff);
+            sink.put1(0x17);
+        }
     }
 
     state.clear_post_insn();
diff --git a/cranelift/codegen/src/isa/x64/inst/emit_tests.rs b/cranelift/codegen/src/isa/x64/inst/emit_tests.rs
index f1e74ae22a..a3e1c9b658 100644
--- a/cranelift/codegen/src/isa/x64/inst/emit_tests.rs
+++ b/cranelift/codegen/src/isa/x64/inst/emit_tests.rs
@@ -3915,6 +3915,17 @@ fn test_x64_emit() {
         "elf_tls_get_addr User { namespace: 0, index: 0 }",
     ));
 
+    insns.push((
+        Inst::MachOTlsGetAddr {
+            symbol: ExternalName::User {
+                namespace: 0,
+                index: 0,
+            },
+        },
+        "488B3D00000000FF17",
+        "macho_tls_get_addr User { namespace: 0, index: 0 }",
+    ));
+
     // ========================================================
     // Actually run the tests!
     let mut flag_builder = settings::builder();
diff --git a/cranelift/codegen/src/isa/x64/inst/mod.rs b/cranelift/codegen/src/isa/x64/inst/mod.rs
index edc7a65109..d1302cacbc 100644
--- a/cranelift/codegen/src/isa/x64/inst/mod.rs
+++ b/cranelift/codegen/src/isa/x64/inst/mod.rs
@@ -480,6 +480,10 @@ pub enum Inst {
     /// A call to the `ElfTlsGetAddr` libcall. Returns address
     /// of TLS symbol in rax.
     ElfTlsGetAddr { symbol: ExternalName },
+
+    /// A Mach-O TLS symbol access. Returns address of the TLS
+    /// symbol in rax.
+    MachOTlsGetAddr { symbol: ExternalName },
 }
 
 pub(crate) fn low32_will_sign_extend_to_64(x: u64) -> bool {
@@ -539,7 +543,8 @@ impl Inst {
             | Inst::XmmLoadConst { .. }
             | Inst::XmmMinMaxSeq { .. }
             | Inst::XmmUninitializedValue { .. }
-            | Inst::ElfTlsGetAddr { .. } => None,
+            | Inst::ElfTlsGetAddr { .. }
+            | Inst::MachOTlsGetAddr { .. } => None,
 
             // These use dynamic SSE opcodes.
             Inst::GprToXmm { op, .. }
@@ -1791,6 +1796,10 @@ impl PrettyPrint for Inst {
             Inst::ElfTlsGetAddr { ref symbol } => {
                 format!("elf_tls_get_addr {:?}", symbol)
             }
+
+            Inst::MachOTlsGetAddr { ref symbol } => {
+                format!("macho_tls_get_addr {:?}", symbol)
+            }
         }
     }
 }
@@ -2051,7 +2060,7 @@ fn x64_get_regs(inst: &Inst, collector: &mut RegUsageCollector) {
             // No registers are used.
         }
 
-        Inst::ElfTlsGetAddr { .. } => {
+        Inst::ElfTlsGetAddr { .. } | Inst::MachOTlsGetAddr { .. } => {
             // All caller-saves are clobbered.
             //
             // We use the SysV calling convention here because the
@@ -2449,6 +2458,7 @@ fn x64_map_regs<RUM: RegUsageMapper>(inst: &mut Inst, mapper: &RUM) {
         | Inst::Hlt
         | Inst::AtomicRmwSeq { .. }
         | Inst::ElfTlsGetAddr { .. }
+        | Inst::MachOTlsGetAddr { .. }
         | Inst::Fence { .. } => {
             // Instruction doesn't explicitly mention any regs, so it can't have any virtual
             // regs that we'd need to remap.  Hence no action required.
diff --git a/cranelift/codegen/src/isa/x64/lower.rs b/cranelift/codegen/src/isa/x64/lower.rs
index 3339f21b24..45014fca17 100644
--- a/cranelift/codegen/src/isa/x64/lower.rs
+++ b/cranelift/codegen/src/isa/x64/lower.rs
@@ -5333,6 +5333,13 @@ fn lower_insn_to_regs<C: LowerCtx<I = Inst>>(
                 ctx.emit(Inst::ElfTlsGetAddr { symbol });
                 ctx.emit(Inst::gen_move(dst, regs::rax(), types::I64));
             }
+            TlsModel::Macho => {
+                let dst = get_output_reg(ctx, outputs[0]).only_reg().unwrap();
+                let (name, _, _) = ctx.symbol_value(insn).unwrap();
+                let symbol = name.clone();
+                ctx.emit(Inst::MachOTlsGetAddr { symbol });
+                ctx.emit(Inst::gen_move(dst, regs::rax(), types::I64));
+            }
             _ => {
                 todo!(
                     "Unimplemented TLS model in x64 backend: {:?}",