diff --git a/Cargo.toml b/Cargo.toml
index 9a604c68c9..3b5e10417b 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -11,10 +11,10 @@ edition = "2018"
 default-run = "wasmtime"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-native = "0.41.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-native = "0.43.1"
 wasmtime-api = { path = "wasmtime-api" }
 wasmtime-debug = { path = "wasmtime-debug" }
 wasmtime-environ = { path = "wasmtime-environ" }
@@ -28,9 +28,9 @@ wasmtime-wasi-c = { path = "wasmtime-wasi-c", optional = true }
 wasi-common = { git = "https://github.com/CraneStation/wasi-common", rev = "8ea7a983d8b1364e5f62d2adf0e74b3b8db1c9b3"}
 docopt = "1.0.1"
 serde = { "version" = "1.0.94", features = ["derive"] }
-faerie = "0.10.1"
+faerie = "0.11.0"
 failure = "0.1"
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 pretty_env_logger = "0.3.0"
 file-per-thread-logger = "0.1.1"
 wabt = "0.9"
@@ -54,3 +54,6 @@ members = [
 default = ["cranelift-codegen/all-arch"]
 lightbeam = ["wasmtime-environ/lightbeam", "wasmtime-jit/lightbeam"]
 wasi-c = ["wasmtime-wasi-c"]
+
+# [patch.crates-io]
+# cranelift-wasm = { path = "../cranelift/cranelift-wasm" }
diff --git a/fuzz/Cargo.toml b/fuzz/Cargo.toml
index cd8d4c4ac4..43697ee7d7 100644
--- a/fuzz/Cargo.toml
+++ b/fuzz/Cargo.toml
@@ -11,9 +11,9 @@ cargo-fuzz = true
 [dependencies]
 wasmtime-environ = { path = "../wasmtime-environ" }
 wasmtime-jit = { path = "../wasmtime-jit" }
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-native = "0.41.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-native = "0.43.1"
 libfuzzer-sys = { git = "https://github.com/rust-fuzz/libfuzzer-sys.git" }
 wasmparser = { version = "0.36.0", default-features = false }
 binaryen = "0.5.0"
diff --git a/fuzz/fuzz_targets/instantiate.rs b/fuzz/fuzz_targets/instantiate.rs
old mode 100644
new mode 100755
index bee084b35d..41a2539163
--- a/fuzz/fuzz_targets/instantiate.rs
+++ b/fuzz/fuzz_targets/instantiate.rs
@@ -23,5 +23,12 @@ fuzz_target!(|data: &[u8]| {
     let isa = isa_builder.finish(settings::Flags::new(flag_builder));
     let mut compiler = Compiler::new(isa);
     let mut imports_resolver = NullResolver {};
-    let _instance = instantiate(&mut compiler, data, &mut imports_resolver).unwrap();
+    let _instance = instantiate(
+        &mut compiler,
+        data,
+        &mut imports_resolver,
+        Default::default(),
+        true,
+    )
+    .unwrap();
 });
diff --git a/fuzz/fuzz_targets/instantiate_translated.rs b/fuzz/fuzz_targets/instantiate_translated.rs
old mode 100644
new mode 100755
index 9d452259fd..af6dfdd460
--- a/fuzz/fuzz_targets/instantiate_translated.rs
+++ b/fuzz/fuzz_targets/instantiate_translated.rs
@@ -21,5 +21,12 @@ fuzz_target!(|data: &[u8]| {
     let isa = isa_builder.finish(settings::Flags::new(flag_builder));
     let mut compiler = Compiler::new(isa);
     let mut imports_resolver = NullResolver {};
-    let _instance = instantiate(&mut compiler, &wasm, &mut imports_resolver).unwrap();
+    let _instance = instantiate(
+        &mut compiler,
+        &wasm,
+        &mut imports_resolver,
+        Default::default(),
+        true,
+    )
+    .unwrap();
 });
diff --git a/misc/wasmtime-py/Cargo.toml b/misc/wasmtime-py/Cargo.toml
index 844a9baee7..d90661e5ba 100644
--- a/misc/wasmtime-py/Cargo.toml
+++ b/misc/wasmtime-py/Cargo.toml
@@ -12,16 +12,16 @@ name = "_wasmtime"
 crate-type = ["cdylib"]
 
 [dependencies]
-cranelift-codegen = "0.41.0"
-cranelift-native = "0.41.0"
-cranelift-entity = "0.41.0"
-cranelift-wasm = "0.41.0"
-cranelift-frontend = "0.41.0"
+cranelift-codegen = "0.43.1"
+cranelift-native = "0.43.1"
+cranelift-entity = "0.43.1"
+cranelift-wasm = "0.43.1"
+cranelift-frontend = "0.43.1"
 wasmtime-environ = { path = "../../wasmtime-environ" }
 wasmtime-interface-types = { path = "../../wasmtime-interface-types" }
 wasmtime-jit = { path = "../../wasmtime-jit" }
 wasmtime-runtime = { path = "../../wasmtime-runtime" }
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 failure = "0.1"
 region = "2.0.0"
 wasmparser = "0.38.0"
diff --git a/misc/wasmtime-rust/Cargo.toml b/misc/wasmtime-rust/Cargo.toml
index 0c7b675d30..6bea1d0b46 100644
--- a/misc/wasmtime-rust/Cargo.toml
+++ b/misc/wasmtime-rust/Cargo.toml
@@ -12,8 +12,8 @@ test = false
 doctest = false
 
 [dependencies]
-cranelift-codegen = "0.41.0"
-cranelift-native = "0.41.0"
+cranelift-codegen = "0.43.1"
+cranelift-native = "0.43.1"
 failure = "0.1.5"
 wasmtime-interface-types = { path = "../../wasmtime-interface-types" }
 wasmtime-jit = { path = "../../wasmtime-jit" }
diff --git a/wasmtime-api/Cargo.toml b/wasmtime-api/Cargo.toml
index 21a51f59c8..70ad083d16 100644
--- a/wasmtime-api/Cargo.toml
+++ b/wasmtime-api/Cargo.toml
@@ -12,18 +12,18 @@ name = "wasmtime_api"
 crate-type = ["lib", "staticlib", "cdylib"]
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-native = "0.41.0"
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-frontend = "0.41.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-native = "0.43.1"
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-frontend = "0.43.1"
 wasmtime-runtime = { path="../wasmtime-runtime" }
 wasmtime-environ = { path="../wasmtime-environ" }
 wasmtime-jit = { path="../wasmtime-jit" }
 wasmparser = "0.36"
 failure = { version = "0.1.3", default-features = false }
 failure_derive = { version = "0.1.3", default-features = false }
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 region = "2.0.0"
 
 [features]
diff --git a/wasmtime-debug/Cargo.toml b/wasmtime-debug/Cargo.toml
index 599418f681..acd59569ef 100644
--- a/wasmtime-debug/Cargo.toml
+++ b/wasmtime-debug/Cargo.toml
@@ -14,12 +14,12 @@ edition = "2018"
 [dependencies]
 gimli = "0.19.0"
 wasmparser = { version = "0.36.0" }
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-faerie = "0.10.1"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+faerie = "0.11.0"
 wasmtime-environ = { path = "../wasmtime-environ", default-features = false }
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 failure = { version = "0.1.3", default-features = false }
 failure_derive = { version = "0.1.3", default-features = false }
 
diff --git a/wasmtime-environ/Cargo.toml b/wasmtime-environ/Cargo.toml
index b43d915a3f..1ae75ed2b0 100644
--- a/wasmtime-environ/Cargo.toml
+++ b/wasmtime-environ/Cargo.toml
@@ -12,9 +12,9 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
 lightbeam = { path = "../lightbeam", optional = true }
 failure = { version = "0.1.3", default-features = false }
 failure_derive = { version = "0.1.3", default-features = false }
@@ -41,10 +41,10 @@ errno = "0.2.4"
 
 [dev-dependencies]
 tempfile = "3"
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 pretty_env_logger = "0.3.0"
 rand = { version = "0.7.0", features = ["small_rng"] }
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde", "all-arch"] }
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde", "all-arch"] }
 
 [features]
 default = ["std"]
diff --git a/wasmtime-interface-types/Cargo.toml b/wasmtime-interface-types/Cargo.toml
index 0017bd6a73..559edbaff9 100644
--- a/wasmtime-interface-types/Cargo.toml
+++ b/wasmtime-interface-types/Cargo.toml
@@ -11,7 +11,7 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = "0.41.0"
+cranelift-codegen = "0.43.1"
 failure = "0.1"
 walrus = "0.11.0"
 wasmparser = "0.36.0"
diff --git a/wasmtime-jit/Cargo.toml b/wasmtime-jit/Cargo.toml
index d69b6c9932..f001c06bed 100644
--- a/wasmtime-jit/Cargo.toml
+++ b/wasmtime-jit/Cargo.toml
@@ -11,17 +11,17 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-frontend = "0.41.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-frontend = "0.43.1"
 wasmtime-environ = { path = "../wasmtime-environ", default-features = false }
 wasmtime-runtime = { path = "../wasmtime-runtime", default-features = false }
 wasmtime-debug = { path = "../wasmtime-debug", default-features = false }
 region = "2.0.0"
 failure = { version = "0.1.3", default-features = false }
 failure_derive = { version = "0.1.3", default-features = false }
-target-lexicon = { version = "0.4.0", default-features = false }
+target-lexicon = { version = "0.8.1", default-features = false }
 hashbrown = { version = "0.6.0", optional = true }
 wasmparser = "0.36.0"
 
diff --git a/wasmtime-obj/Cargo.toml b/wasmtime-obj/Cargo.toml
index 702109247e..458232b519 100644
--- a/wasmtime-obj/Cargo.toml
+++ b/wasmtime-obj/Cargo.toml
@@ -11,8 +11,8 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
 wasmtime-environ = { path = "../wasmtime-environ" }
-faerie = "0.10.1"
+faerie = "0.11.0"
diff --git a/wasmtime-runtime/Cargo.toml b/wasmtime-runtime/Cargo.toml
index ae5898747e..f8bf9c9de3 100644
--- a/wasmtime-runtime/Cargo.toml
+++ b/wasmtime-runtime/Cargo.toml
@@ -11,9 +11,9 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
 wasmtime-environ = { path = "../wasmtime-environ", default-features = false }
 region = "2.0.0"
 lazy_static = "1.2.0"
diff --git a/wasmtime-runtime/src/instance.rs b/wasmtime-runtime/src/instance.rs
index c6c92590b3..603851ac9c 100644
--- a/wasmtime-runtime/src/instance.rs
+++ b/wasmtime-runtime/src/instance.rs
@@ -1260,6 +1260,7 @@ fn initialize_globals(instance: &mut Instance) {
             GlobalInit::I64Const(x) => *unsafe { (*to).as_i64_mut() } = x,
             GlobalInit::F32Const(x) => *unsafe { (*to).as_f32_bits_mut() } = x,
             GlobalInit::F64Const(x) => *unsafe { (*to).as_f64_bits_mut() } = x,
+            GlobalInit::V128Const(x) => *unsafe { (*to).as_u128_bits_mut() } = x.0,
             GlobalInit::GetGlobal(x) => {
                 let from = if let Some(def_x) = module.defined_global_index(x) {
                     instance.global_mut(def_x)
diff --git a/wasmtime-runtime/src/vmcontext.rs b/wasmtime-runtime/src/vmcontext.rs
index 1f7721a47b..74d79f72d2 100644
--- a/wasmtime-runtime/src/vmcontext.rs
+++ b/wasmtime-runtime/src/vmcontext.rs
@@ -382,6 +382,30 @@ impl VMGlobalDefinition {
     pub unsafe fn as_f64_bits_mut(&mut self) -> &mut u64 {
         &mut *(self.storage.as_mut().as_mut_ptr() as *mut u64)
     }
+
+    /// Return a reference to the value as an u128.
+    #[allow(clippy::cast_ptr_alignment)]
+    pub unsafe fn as_u128(&self) -> &u128 {
+        &*(self.storage.as_ref().as_ptr() as *const u128)
+    }
+
+    /// Return a mutable reference to the value as an u128.
+    #[allow(clippy::cast_ptr_alignment)]
+    pub unsafe fn as_u128_mut(&mut self) -> &mut u128 {
+        &mut *(self.storage.as_mut().as_mut_ptr() as *mut u128)
+    }
+
+    /// Return a reference to the value as u128 bits.
+    #[allow(clippy::cast_ptr_alignment)]
+    pub unsafe fn as_u128_bits(&self) -> &[u8; 16] {
+        &*(self.storage.as_ref().as_ptr() as *const [u8; 16])
+    }
+
+    /// Return a mutable reference to the value as u128 bits.
+    #[allow(clippy::cast_ptr_alignment)]
+    pub unsafe fn as_u128_bits_mut(&mut self) -> &mut [u8; 16] {
+        &mut *(self.storage.as_mut().as_mut_ptr() as *mut [u8; 16])
+    }
 }
 
 /// An index into the shared signature registry, usable for checking signatures
diff --git a/wasmtime-wasi-c/Cargo.toml b/wasmtime-wasi-c/Cargo.toml
index 8f6d92f62c..ffc8566bc8 100644
--- a/wasmtime-wasi-c/Cargo.toml
+++ b/wasmtime-wasi-c/Cargo.toml
@@ -12,10 +12,10 @@ readme = "README.md"
 wasmtime-runtime = { path = "../wasmtime-runtime" }
 wasmtime-environ = { path = "../wasmtime-environ" }
 wasmtime-jit = { path = "../wasmtime-jit" }
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-target-lexicon = "0.4.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+target-lexicon = "0.8.1"
 log = { version = "0.4.8", default-features = false }
 libc = "0.2.60"
 
diff --git a/wasmtime-wasi/Cargo.toml b/wasmtime-wasi/Cargo.toml
index 420eee6be1..0fca505d38 100644
--- a/wasmtime-wasi/Cargo.toml
+++ b/wasmtime-wasi/Cargo.toml
@@ -14,10 +14,10 @@ wasmtime-runtime = { path = "../wasmtime-runtime" }
 wasmtime-environ = { path = "../wasmtime-environ" }
 wasmtime-jit = { path = "../wasmtime-jit" }
 wasi-common = { git = "https://github.com/CraneStation/wasi-common", rev = "8ea7a983d8b1364e5f62d2adf0e74b3b8db1c9b3"}
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
-target-lexicon = "0.4.0"
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
+target-lexicon = "0.8.1"
 log = { version = "0.4.8", default-features = false }
 
 [badges]
diff --git a/wasmtime-wast/Cargo.toml b/wasmtime-wast/Cargo.toml
index 2939c77c6c..80e9040916 100644
--- a/wasmtime-wast/Cargo.toml
+++ b/wasmtime-wast/Cargo.toml
@@ -11,14 +11,14 @@ readme = "README.md"
 edition = "2018"
 
 [dependencies]
-cranelift-codegen = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-entity = { version = "0.41.0", features = ["enable-serde"] }
-cranelift-wasm = { version = "0.41.0", features = ["enable-serde"] }
+cranelift-codegen = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-entity = { version = "0.43.1", features = ["enable-serde"] }
+cranelift-wasm = { version = "0.43.1", features = ["enable-serde"] }
 wasmtime-jit = { path = "../wasmtime-jit" }
 wasmtime-runtime = { path = "../wasmtime-runtime" }
 wasmtime-environ = { path = "../wasmtime-environ" }
 wabt = "0.9.1"
-target-lexicon = "0.4.0"
+target-lexicon = "0.8.1"
 failure = { version = "0.1.3", default-features = false }
 failure_derive = { version = "0.1.3", default-features = false }